Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR /PGC1 and thermogenic glycerolipid/fatty acid cycling
نویسندگان
چکیده
J. Eduardo Rame,* Lili A. Barouch,* Michael N. Sack, Edward G. Lynn, Mones Abu-Asab, Maria Tsokos, Steven J. Kern, Jennifer J. Barb, Peter J. Munson, Marc K. Halushka, Karen L. Miller, Karen Fox-Talbot, Jianhua Zhang, Joshua M. Hare, Michael A. Solomon, and Robert L. Danner Cardiovascular Medicine Division, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Cardiology, Johns Hopkins University, Baltimore; Translational Medicine Branch, National Heart, Lung and Blood Institute, Laboratory of Pathology, National Cancer Institute, Functional Genomics and Proteomics Facility, Critical Care Medicine Department, Clinical Center, Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda; Department of Pathology, Johns Hopkins University, Baltimore, Maryland; Interdisciplinary Stem Cell Institute, Cardiovascular Division, Department of Medicine, University of Miami School of Medicine, Miami, Florida
منابع مشابه
Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice.
By supplying most organs of the body with metabolic substrates, the liver plays a central role in maintaining energy balance. Hepatic metabolism of glucose, fatty acids, and lipoproteins is disrupted in the leptin-deficient obese (Lep(ob)/Lep(ob)) mouse, leading to hyperglycemia, steatosis, and hypercholesterolemia. Microarray expression profiles were used to identify transcriptional perturbati...
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